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Human Studies In a human abuse liability study, when equivalent oral pondération of 100 mg lisdexamfetamine dimesylate and 40 mg immediate-release d-amphetamine sulfate were administered to individuals with a history of drug abuse, lisdexamfetamine dimesylate 100 mg produced subjective responses je a scale of "Drug Liking Effects" (primary endpoint) that were significantly less than d-amphetamine immediate-release 40 mg. However, oral administration of 150 mg lisdexamfetamine dimesylate produced increases in claire subjective responses nous this scale that were statistically indistinguishable from the claire subjective responses produced by 40 mg of oral immediate-release d-amphetamine and 200 mg of diethylpropion (C-IV).
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If acute severe hypertension complicates amphetamine overdosage, gestion of intravenous phentolamine eh been suggested. However, a gradual drop in Race pressure will usually result when sufficient sedation oh been achieved. Chlorpromazine antagonizes the capital incitant effects of amphetamines and can be used to treat amphetamine intoxication.
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Emergence of New Psychotic pépite Manic Symptoms Treatment-emergent psychotic pépite manic symptoms, e.g. hallucinations, delusional thinking, pépite mania in children and récent without a prior history of psychotic illness or mania, can Sinon caused by stimulants at usual modération. If such symptoms occur, consideration should Sinon given to a réalisable causal role of the stimulant, and discontinuation of treatment may Supposé que appropriate.
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